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Anhedonia, Development, and Emotions: Phenotyping and Therapeutics (ADEPT) Study 

This study is sponsored by the Wellcome Leap: Multi-Channel Psych Program 

The goal of the ADEPT Study is to understand anhedonia in young people and how it changes based on treatments targeting the brain circuit underlying it. Anhedonia is a challenging mental health symptom that involves difficulty with motivation to experience pleasant events. This study could help develop treatments for people whose depression does not improve with traditional treatments. IRB: STUDY21120080, NCT05487885

The ADEPT Study includes two phases:

  1. Phase 1 includes a series of activities to measure anhedonia, including an MRI scan, blood draw, behavioral task, clinical interview, questionnaires, and app-based assessments of experiences and behaviors.
  2. Phase 2 involves therapeutic activities, such as transcranial magnetic stimulation (TMS), positive affect training, and, for some people, ketamine administration.

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