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Treatment, Emotion, Neuromodulation, Depression (TREND) Study

Depression is a chronic, impairing form of psychopathology that is one of the world’s leading causes of disability. Brain connectivity and activity in a region in the prefrontal cortex (the dmPFC) has recently been identified as a biomarker for some types of depression. In addition to this, other studies have shown changes in dmPFC connectivity after transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique that manipulates cortical excitability, in people with depression. In this study, we will build upon these prior findings to further explore the feasibility of stimulation to alter neural activity and connectivity, using a mix of functional MRI and TMS to examine the acute effects of theta-burst stimulation (TBS) to the dmPFC in 36 young adults with depression (18-25 years). Participation involves 5 trips into the lab and includes an interview, questionnaires, computer tasks, fMRI scans, and theta-burst stimulation. Learn more through Pitt+Me

IRB: STUDY21060041, ID: NCT05436379

If you are interested in participating in the TREND study, please take this short survey!


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